Endocrine Abstracts

Introduction: The prevalence of B-type Raf kinase (BRAFV600E) mutation in PTC has been observed in 30% to over 80%, and it seems that the mutation occurred in the early stage of thyroid carcinoma progression which precedes histological change. Based on previous reports, high body mass index (BMI) is considered a thyroid cancer risk. However, it is unclear whether high BMI has a certain association with the BRAFV600E mutational status. We assess whether high BMI is associated w...

Background: Telomerase reverse transcriptase (TERT) promoter mutation is a poor prognostic factor in differentiated thyroid carcinoma(DTC). It is thought to play a role in the transformation process to undifferentiated thyroid carcinoma(UTC), but its role as a prognostic factor in UTC is unclear. Therefore, in this study, we investigated whether the TERT promoter mutation acts as as an independent poor prognostic factor in UTC.Methods: Among patients dia...

Background: Delayed thyroid-stimulating hormone (TSH) recovery during treatment of Graves’ disease is caused by long-term excessive thyroid hormone, which results in down-regulation of pituitary thyrotropic cells. However, it is unknown whether delayed TSH recovery exists after levothyroxine (LT4) dose adjustment in patients with differentiated thyroid cancer (DTC) who are taking a suppressive dose of LT4.Methods: We retrospectively reviewed 97 DTC ...

Background: The incidence and prevalence of overt hypothyroidism have been reported to be 2 to 4/1,000 population/year and 8 to 13/1,000 population, respectively, in foreign countries. As there has been no nationwide survey to obtain data in Korea, the present study investigated the incidence and prevalence of overt hypothyroidism in Korea using claims data provided by the Health Insurance Review and Assessment Service. The proportions of causative diseases for hypothyroidism ...

Background: Selenium is an important trace element for thyroid hormone metabolism and its deficiency can cause hypothyroidism. Serum or plasma selenium concentration has been known as best biomarker which reflects selenium intake and reserve. We preliminarily assessed the serum or urine selenium concentrations in patients with thyroid disease compared to healthy normal population. We also investigated the correlation of serum selenium concentration with urine selenium concentr...

Objectives: 18F-choline PET/CT is a recently introduced imaging modality to localize hyperfunctioning parathyroid glands in patient with hyperparathyroidism. But there has been no study according the diagnostic power of 18F-choline PET/CT in Korea so far owing to its limited distribution. Therefore, we evaluated the diagnostic performance of 18F-choline PET/CT in detection of hyperfunctioning parathyroid gland in patients with primary hyperpara...